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These include the induction ofp53-mediated apoptosis, but notably not growth arrest [164], reecting altered spec -icity of p53 for apoptotic target genes versus growth arrest promoting genes [ 165].Subsequent attempts to clarify the genes that are activated both in humans and micehave led to some contradictory ndings [ 166]. Few studies compared theefficacy of Gram with other staining procedures [32], for example, acridine orange, orevaluated different patient populations, such as those with prosthetic joint infections[16, 33], various immunocompromising conditions, or concomitant gout [28, 30] andother microcrystalline diseases [34, 35]. Rathakrishnan et al studied a variation of previously described qEEGparameters termed composite alpha index (CAI).

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